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Because in silico evaluation of Fer-1 analogs' P450 stability using the Schrodinger Suite P450_SOM program showed agreement with the experimental results with liver microsomes, this computer program is used to guide prioritization of compound synthesis and testing of analogs proposed based on modifications known to inhibit metabolism

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This study was carried out in accordance with the recommendations of the respective Institutional Review Boards (IRBs), described below with written informed consent from parents of subjects and assent where appropriate

Also, a recent meta-analysis found that arsenic exposure through drinking water is associated with low levels of HDL and high levels of LDL, while it was not associated with plasmatic triglyceride and total cholesterol levels (116)